反応 #41720

反応方程式

2-bromo-5-methoxybenzthiazole

4-Bromoaniline

→

desired product

(4-bromophenyl)(5-methoxybenzothiazol-2-yl)amine

溶媒

NMP

反応条件

後処理

1. 1
   濃縮The resultant mixture was concentrated
2. 2
   その他partitioned between ethyl acetate and water
3. 3
   洗浄The organic layer was washed with brine
4. 4
   その他dried
5. 5
   その他Purification on silica gel

実験手順

The mixture containing 2-bromo-5-methoxybenzthiazole (1 eq), 4-Bromoaniline (2 eq) and disopropylethylamine was subjected to microwave in NMP at 220° C. The resultant mixture was concentrated and partitioned between ethyl acetate and water. The organic layer was washed with brine and dried. Purification on silica gel gave the desired product. MS: MH+=335

出典