反応 #41700

反応方程式

hydrogen

N-(4-((4R)-4-((tert-butyl(dimethyl)silyl)oxy)-2-pentynoyl)-3-fluorophenyl)pyrazine-2-carboxamide

→

compound

N-(4-((4R)-4-((tert-butyl(dimethyl)silyl)oxy)-pentanoyl)-3-fluorophenyl)pyrazine-2-carboxamide

溶媒

tetrahydrofuran

ethanol

反応条件

後処理

1. 1
   その他the reaction liquid
2. 2
   その他The catalyst was removed through filtration
3. 3
   その他the solvent was evaporated away under reduced pressure
4. 4
   その他the resulting residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate=9/1 to 1/1)

実験手順

100 mg of 10% palladium-carbon catalyst was added to a solution of 513 mg of N-(4-((4R)-4-((tert-butyl(dimethyl)silyl)oxy)-2-pentynoyl)-3-fluorophenyl)pyrazine-2-carboxamide in 5 ml of tetrahydrofuran and 20 ml of ethanol, and the reaction liquid was stirred in a hydrogen atmosphere for 1.5 hours. The catalyst was removed through filtration, the solvent was evaporated away under reduced pressure, and the resulting residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate=9/1 to 1/1) to obtain the entitled compound as a pale yellow solid.

出典