反応 #41698

反応方程式

pyrazine-2-carboxylic acid

1-ethyl-3-(3′-dimethylaminopropyl)-carbodiimide hydrochloride

4-amino-2-fluoro-N-methoxy-N-methylbenzamide

→

compound

N-(3-fluoro-4-((N-methoxy-N-methylamino)carbonyl)phenyl)pyrazine-2-carboxamide

溶媒

pyridine

反応条件

後処理

1. 1
   その他the reaction liquid
2. 2
   その他Pyridine was evaporated away under reduced pressure
3. 3
   workup.ADDITIONthe residue was diluted with ethyl acetate
4. 4
   洗浄washed with water
5. 5
   乾燥dried with anhydrous magnesium sulfate
6. 6
   その他The solvent was evaporated away under reduced pressure
7. 7
   洗浄the resulting solid was washed with a mixed solvent of ethyl acetate and hexane

実験手順

2.56 g of pyrazine-2-carboxylic acid and 4.66 g of 1-ethyl-3-(3′-dimethylaminopropyl)-carbodiimide hydrochloride were added to a pyridine (20 ml) solution of 3.7 g of 4-amino-2-fluoro-N-methoxy-N-methylbenzamide, and the reaction liquid was stirred at room temperature for 1 hour. Pyridine was evaporated away under reduced pressure, and the residue was diluted with ethyl acetate, washed with water, and dried with anhydrous magnesium sulfate. The solvent was evaporated away under reduced pressure, and the resulting solid was washed with a mixed solvent of ethyl acetate and hexane to obtain the entitled compound as a pale yellow solid.

出典