反応 #41656

反応方程式

hydroxyamine

5-(2-fluoro-phenoxy)-2-pyrazin-2-yl-6-(6-cyano-pyridin-3-yloxy)-1H-benzimidazole

5-(2-Fluoro-phenoxy)-2-pyrazin-2-yl-6-(6-cyano-pyridin-3-yloxy)-1H-benzimidazole

ethanol

→

compound

5-(2-Fluoro-phenoxy)-2-pyrazin-2-yl-6-(4-(N-hydroxycarbamimidoyl)-phenoxy)-1H-benzimidazole

反応条件

後処理

1. 1
   その他the reaction liquid
2. 2
   その他Then, the solvent was evaporated away under reduced pressure

実験手順

0.5 ml of hydroxyamine (50% aqueous solution) was added to an ethanol (0.5 ml) solution of 6.0 mg of 5-(2-fluoro-phenoxy)-2-pyrazin-2-yl-6-(6-cyano-pyridin-3-yloxy)-1H-benzimidazole obtained in Example 252, and the reaction liquid was stirred at room temperature for 3 hours. Then, the solvent was evaporated away under reduced pressure to obtain the entitled compound as a pale yellow solid.

出典