反応 #41551
ord-50ff626390254e4b8c9004508484924c
反応方程式
反応物
試薬
反応条件
後処理
- 1その他the reaction liquid
- 2その他the reaction liquid
- 3workup.STIRRINGwas stirred overnight at room temperature
- 4抽出this was extracted with ethyl acetate
- 5乾燥dried with anhydrous magnesium sulfate
- 6その他The solvent was evaporated away under reduced pressure
- 7その他the resulting residue was purified
- 8その他through partitioning thin-layer chromatography (Kieselgel™ 60F254, Art 5744 (by Merck), ethyl acetate)
- 9その他to obtain the entitled compound as a brown oily substance
実験手順
0.019 ml of diisopropylamine, 27.6 mg of triphenyl phosphine and 0.011 ml of 2-phenyl-ethanol were added in order to a tetrahydrofuran (1 ml) solution of 29.2 mg of 1-(2-(6-hydroxy-2-pyridin-2-yl-3-(2-trimethylsilanyl-ethoxymethyl)-3H-benzimidazol-5-yl)pyrrolidin-1-yl)-ethanone obtained in Example 121 (step 10), and the reaction liquid was stirred for 6 hours at room temperature. 0.040 ml of diisopropylamine, 53.2 mg of triphenyl phosphine and 0.023 ml of 2-phenyl-ethanol were added in order to the reaction liquid, and the reaction liquid was stirred overnight at room temperature. Aqueous saturated sodium bicarbonate was added to the reaction liquid, and this was extracted with ethyl acetate, and dried with anhydrous magnesium sulfate. The solvent was evaporated away under reduced pressure, and the resulting residue was purified through partitioning thin-layer chromatography (Kieselgel™ 60F254, Art 5744 (by Merck), ethyl acetate) to obtain the entitled compound as a brown oily substance.