反応 #41528

反応方程式

carbon disulfide

potassium hydroxide

ethanol

3-(4-fluoro-phenoxy)-5-(pyridin-3-yloxy)-benzene-1,2-diamine

4-(4-Fluoro-phenoxy)-2-pyridin-2-yl-6-(pyridin-3-yloxy)-1H-benzimidazole

→

4-(4-fluoro-phenoxy)-6-(pyridin-3-yloxy)-1H-benzimidazole-2-thiol

溶媒

ethyl acetate

反応条件

後処理

1. 1
   その他the reaction liquid
2. 2
   その他The reaction liquid
3. 3
   洗浄washed with water and saturated saline in order
4. 4
   乾燥dried with anhydrous magnesium sulfate
5. 5
   その他The solvent was evaporated away under reduced pressure
6. 6
   その他to obtain the entitled compound

実験手順

0.06 ml of carbon disulfide and 54 mg of potassium hydroxide were added to an ethanol (2.0 ml) solution of 273 mg of 3-(4-fluoro-phenoxy)-5-(pyridin-3-yloxy)-benzene-1,2-diamine obtained in Example 68, and the reaction liquid was stirred overnight at 80° C. The reaction liquid was diluted with ethyl acetate, washed with water and saturated saline in order, and dried with anhydrous magnesium sulfate. The solvent was evaporated away under reduced pressure to obtain the entitled compound.

出典