反応 #41344

反応方程式

5-Iodo-6-methylindazole

p-fluorobenzeneboronic acid

pyridine

p-fluorobenzeneboronic acid

pyridine

→

subtitle compound

収率 51.1%

1-(4-Fluorophenyl)-5-iodo-6-methylindazole

収率 51.1%

溶媒

dichloromethane

反応条件

後処理

1. 1
   ろ過The mixture was filtered through celite
2. 2
   濃縮The filtrate was concentrated
3. 3
   その他purified by column chromatography (SiO2, toluene)

実験手順

5-Iodo-6-methylindazole (1.3 g, 5.0 mmol), p-fluorobenzeneboronic acid (1.4 g, 10 mmol), anhydrous copper(II) acetate (1.4 g, 7.5 mmol) and pyridine (0.80 mL, 10 mmol) were stirred in dichloromethane (30 mL) overnight. Additional portions of p-fluorobenzeneboronic acid (0.47 g, 3.4 mmol), anhydrous copper(II) acetate (0.45 g, 2.5 mmol) and pyridine (0.27 mL, 3.4 mmol) were added. The mixture was filtered through celite after stirring for an additional night. The filtrate was concentrated and purified by column chromatography (SiO2, toluene) to give the subtitle compound (0.90 g, 51%) as a light orange powder.

出典