反応 #413232

反応方程式

2,6-dichloroquinoline

4-aminophenol

hydrochloric acid

→

4-[N-(6-chloro-2-quinolinyl)-amino]phenol

収率 33.0%

溶媒

ethanol

反応条件

後処理

1. 1
   温度refluxed for 10 hours
2. 2
   その他The solvent was removed under reduced pressure
3. 3
   その他the residue partitioned between ethyl acetate and water
4. 4
   その他The ethyl acetate extracts on evaporation

実験手順

A mixture of 2,6-dichloroquinoline (6.0 g), 4-aminophenol (3.3 g), hydrochloric acid (3 g) and ethanol (100 ml) was stirred and refluxed for 10 hours. The solvent was removed under reduced pressure and the residue partitioned between ethyl acetate and water. The ethyl acetate extracts on evaporation gave 4-[N-(6-chloro-2-quinolinyl)-amino]phenol (2.7 g) as a brown solid.

出典