反応 #412314

反応方程式

dimethyl malonate

dec-9-en-1-ol

sodium methoxide

→

yellow oil

収率 59.7%

Malonic acid didec-9-enyl ester

収率 59.7%

溶媒

methanol

反応条件

後処理

1. 1
   workup.ADDITIONwas dropped in
2. 2
   その他formed
3. 3
   workup.DISTILLATIONwas distilled off
4. 4
   温度the mixture was cooled down
5. 5
   workup.ADDITIONdiluted with ether
6. 6
   洗浄washed with HCl 2N, saturated sodium bicarbonate and water
7. 7
   その他The organic phase was dried
8. 8
   ろ過filtered
9. 9
   その他evaporated to dryness
10. 10
    workup.DISTILLATIONThe resulting yellow oil was purified by distillation

実験手順

To a mixture of 150 g dimethyl malonate and 464 g dec-9-en-1-ol, 30 g sodium methoxide (5.4 M in methanol) was dropped in. The mixture was heated to 120° C. to and the methanol formed was distilled off. After 6 hours, the mixture was cooled down, diluted with ether and washed with HCl 2N, saturated sodium bicarbonate and water. The organic phase was dried, filtered and evaporated to dryness. The resulting yellow oil was purified by distillation to yield 258 g of a yellow oil.

出典