反応 #41144

反応方程式

methyl acetoacetate

N,N-dimethylformamide dimethylacetal

→

2-dimethylaminomethylene-3-oxo-butyric acid methyl ester

収率 94.0%

反応条件

後処理

1. 1
   濃縮was then concentrated in vacuo

実験手順

A solution of methyl acetoacetate (5.0 mL, 46.33 mmol) and N,N-dimethylformamide dimethylacetal (6.8 mL, 47.95 mmol) was heated to 80° C. for 2.3 h. At this time, the reaction was cooled to 25° C. and was then concentrated in vacuo to afford 2-dimethylaminomethylene-3-oxo-butyric acid methyl ester (7.43 g, 94%) as a red/black solid. This material was used without further purification.

出典