反応 #41139

反応方程式

5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide

azepane

→

5-Azepan-1-yl-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide

反応条件

後処理

1. 1
   温度Heating
2. 2
   その他under microwave irradiation
3. 3
   その他provided
4. 4
   その他after purification by reverse phase HPLC, 5-azepan-1-yl-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (41 mg, 58%) as an off-white powder

実験手順

Heating a mixture of 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (Example 5, 60 mg; 0.20 mmol) and azepane (0.23 mL; 2.0 mmol) to 250° C. under microwave irradiation according to the procedure described in Example 14 provided after purification by reverse phase HPLC, 5-azepan-1-yl-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (41 mg, 58%) as an off-white powder. ES-HRMS m/e calcd for C21H33N4O (M+H+) 357.2649, found 357.2644.

出典