反応 #41127

反応方程式

5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide

N-benzylpiperazine

→

5-(4-Benzyl-piperazin-1-yl)-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide

反応条件

後処理

1. 1
   温度Heating
2. 2
   その他under microwave irradiation
3. 3
   その他provided
4. 4
   その他after purification by reverse phase HPLC, 5-(4-benzyl-piperazin-1-yl)-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (50 mg, 38%) as an off-white powder

実験手順

Heating a mixture of 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (Example 5, 88 mg; 0.30 mmol) and N-benzylpiperazine (0.54 mL; 3.1 mmol) under microwave irradiation according to the procedure described for Example 14 provided after purification by reverse phase HPLC, 5-(4-benzyl-piperazin-1-yl)-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (50 mg, 38%) as an off-white powder. ES-HRMS m/e calcd for C26H35N5O (M+H+) 434.2915, found 434.2910.

出典