反応 #41123

反応方程式

5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide

morpholine

→

Methyl-5-morpholin-4-yl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide

反応条件

後処理

1. 1
   温度Heating
2. 2
   その他under microwave irradiation for 4 hr
3. 3
   その他provided
4. 4
   その他after purification by reverse phase HPLC, 1-methyl-5-morpholin-4-yl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (76 mg, 74%) as an off-white powder

実験手順

Heating a mixture of 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (Example 5, 88 mg; 0.30 mmol) and morpholine (0.26 mL; 3.0 mmol) under microwave irradiation for 4 hr according to the procedure described for Example 14 provided after purification by reverse phase HPLC, 1-methyl-5-morpholin-4-yl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (76 mg, 74%) as an off-white powder. ES-HRMS m/e calcd for C19H28N4O2 (M+H+) 345.2285, found 345.2282.

出典