反応 #41118

反応方程式

5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide

pyrrolidine

→

Methyl-5-pyrrolidin-1-yl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide

反応条件

後処理

1. 1
   温度Heating
2. 2
   その他under microwave irradiation
3. 3
   その他provided
4. 4
   その他after purification by reverse phase HPLC, 1-methyl-5-pyrrolidin-1-yl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (60 mg, 61%) as an off-white powder

実験手順

Heating a mixture of 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (Example 5, 88 mg; 0.30 mmol) and pyrrolidine (0.25 mL; 3.0 mmol) under microwave irradiation according to the procedure described for Example 14 provided after purification by reverse phase HPLC, 1-methyl-5-pyrrolidin-1-yl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (60 mg, 61%) as an off-white powder. ES-HRMS m/e calcd for C19H29N4O (M+H+) 329.2336, found 329.2334.

出典