反応 #410851

反応方程式

4-hydroxyphenyl benzoate

potassium carbonate

1,1,3-trichloropropene

N,N-dimethylformamide

→

4-(3,3-dichloro-2-propenyloxy)phenyl benzoate

収率 96.0%

溶媒

water

反応条件

後処理

1. 1
   抽出extracted twice with 150 ml of diethyl ether
2. 2
   洗浄washed with water
3. 3
   乾燥dried over anhydrous magnesium sulfate
4. 4
   濃縮concentrated
5. 5
   その他to give a crude product

実験手順

A reaction vessel was charged with 30.5 g of 4-hydroxyphenyl benzoate, 21.6 g of potassium carbonate, 20.8 g of 1,1,3-trichloropropene and 100 ml of N,N-dimethylformamide. After stirring at room temperature for 15 hours, the reaction mixture was poured into water and extracted twice with 150 ml of diethyl ether. The ether layers were combined, washed with water, dried over anhydrous magnesium sulfate, and then concentrated to give a crude product. The crude product was subjected to silica gel chromatography, which afforded 44.1 g of 4-(3,3-dichloro-2-propenyloxy)phenyl benzoate (96% yield).

出典