反応 #410164

反応方程式

2-bromo-5-methoxy-benzaldehyde

ethylene glycol

→

2-(2-bromo-5-methoxyphenyl)-[1,3]dioxolane

収率 95.2%

溶媒

toluene

反応条件

後処理

1. 1
   温度is heated
2. 2
   温度at reflux for 5 hours
3. 3
   その他to remove water
4. 4
   その他formed in the reaction
5. 5
   洗浄The reaction mixture is washed five times with water (500 mL)
6. 6
   その他evaporated

実験手順

A mixture of 2-bromo-5-methoxy-benzaldehyde (45.25 g), ethylene glycol (52.22 g) and 4-toluenesulphonic acid (0.4 g) in toluene (400 mL) is heated at reflux for 5 hours using a Dean and Stark apparatus to remove water formed in the reaction. The reaction mixture is washed five times with water (500 mL) and evaporated giving 2-(2-bromo-5-methoxyphenyl)-[1,3]dioxolane (51.9 g) as a yellow liquid.

出典