反応 #409888

反応方程式

N-(L-alaninyl)-L-phenylalanine methyl ester

N-BOC-L-alanine

L-phenylalanine methyl ester

→

title compound

N-[N-(Pent-4-enoyl)-L-alaninyl]-L-phenylalanine Methyl Ester

溶媒

—

EtOAc hexanes

CH3OH CH2Cl2

反応条件

後処理

1. 1
   その他prepared
2. 2
   その他followed by removal of the BOC-group
3. 3
   その他the product was purified by flash chromatography

実験手順

Following General Procedure A and using N-(L-alaninyl)-L-phenylalanine methyl ester (prepared by coupling N-BOC-L-alanine (Sigma) and L-phenylalanine methyl ester (Sigma) using General Procedure A, followed by removal of the BOC-group using General Procedure Y) and pent-4-enoic acid (Aldrich), the title compound was prepared as a solid (mp=125.5-126.5° C.). The reaction was monitored by tlc (Rf=0.32 in 50% EtOAc/hexanes; 0.51 in 10% CH3OH/CH2Cl2) and the product was purified by flash chromatography using 10% CH3OH/CH2Cl2 as the eluent.

出典