反応 #409624

反応方程式

1-[4-(4-hydroxyphenyl)butyl]imidazole

4-chloromethyl-2-(5-methyl-2-thienyl)oxazole

→

4-[4-[4-(1-imidazolyl)butyl]phenoxymethyl]-2-(5-methyl-2-thienyl)oxazole

収率 65.0%

反応条件

実験手順

In substantially the same manner as in Working Example 109, 1-[4-(4-hydroxyphenyl)butyl]imidazole was allowed to react with 4-chloromethyl-2-(5-methyl-2-thienyl)oxazole to give 4-[4-[4-(1-imidazolyl)butyl]phenoxymethyl]-2-(5-methyl-2-thienyl)oxazole. The yield was 65%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 82-83° C.

出典