反応 #40954

反応方程式

water

3-Benzoyl-5-iodo-1H-pyrimidine-2,4-dione

K2CO3

1-bromo-4-chloro-butane

→

title compound

収率 98.0%

3-Benzoyl-1-(4-chloro-butyl)-5-iodo-1H-pyrimidine-2,4-dione

収率 98.0%

溶媒

DMF

反応条件

後処理

1. 1
   workup.ADDITIONwas added
2. 2
   抽出the mixture was extracted with ethyl acetate
3. 3
   乾燥The organic phase was dried (Na2SO4)
4. 4
   ろ過filtered
5. 5
   その他evaporated
6. 6
   その他the crude was purified by flash chromatography with petroleum ether-ethyl acetate (7-3)

実験手順

3-Benzoyl-5-iodo-1H-pyrimidine-2,4-dione (Prep36, 2.5 g, 7.3 mmol), K2CO3 (1 g, 7.3 mmol) and 1-bromo-4-chloro-butane (2.10 mL, 18 mmol) were suspended in dry DMF (10 mL). After stirring the reaction at room temperature overnight, water was added and the mixture was extracted with ethyl acetate. The organic phase was dried (Na2SO4), filtered and evaporated; the crude was purified by flash chromatography with petroleum ether-ethyl acetate (7-3) to give the title compound as a white solid (3 g, 98% yield).

出典