反応 #40951

反応方程式

Water

3-Benzoyl-5-iodo-1H-pyrimidine-2,4-dione

K2CO3

bromo-chloro-propane

→

title compound

収率 98.1%

3-Benzoyl-1-(3-chloro-propyl)-5-iodo-1H-pyrimidine-2,4-dione

収率 98.1%

溶媒

DMF

反応条件

後処理

1. 1
   workup.STIRRINGthe mixture stirred at room temperature overnight
2. 2
   抽出the mixture was extracted with ethyl acetate
3. 3
   乾燥The organic phase was dried (Na2SO4)
4. 4
   ろ過filtered
5. 5
   その他evaporated

実験手順

3-Benzoyl-5-iodo-1H-pyrimidine-2,4-dione (Prep36, 3 g, 8.77 mmol) and K2CO3 (1.2 g, 8.77 mmol) were suspended in dry DMF (45 mL) and stirred at room temperature for 1 h. Then, bromo-chloro-propane (2.7 mL, 17.5 mmol) was added dropwise and the mixture stirred at room temperature overnight. Water was added and the mixture was extracted with ethyl acetate. The organic phase was dried (Na2SO4), filtered and evaporated to give the title compound as a pale yellow oil (3.6 g, 98% yield).

出典