反応 #40833

反応方程式

trimethylaluminum

6-phenyl-5-(4-trifluoromethyl-phenyl)-pyridine-2-carboxylic acid ethyl ester

ethyl 6-phenyl-5-(4-trifluoromethylphenyl)-pyridine-2-carboxylate

Compound 25

ethyl 6-phenyl-5-(4-trifluoromethylphenyl)-pyridine-2-carboxylate

toluene

N,N′-dimethylethylenediamine

→

title compound

1-[6-Phenyl-5-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-ethanone

反応条件

後処理

1. 1
   その他were reacted

実験手順

Following General Procedure O, 6-phenyl-5-(4-trifluoromethyl-phenyl)-pyridine-2-carboxylic acid ethyl ester (Compound 25, 49 mg, 0.13 mmol) in toluene (3 ml), N,N′-dimethylethylenediamine (DMEDA, 13 mg, 0.15 mmol) and trimethylaluminum (0.2 ml, 2.64 mmol, 2 M in toluene) were reacted to produce the title compound as a yellow oil.

出典