反応 #4082

反応方程式

cholesta-1,4,6-trien-3-one

methanesulfonic acid

isopropenyl acetate

→

cholesta-1,5,7-trien-3-ol

収率 61.2%

溶媒

toluene

反応条件

後処理

1. 1
   温度the resulting mixture was then heated
2. 2
   温度under reflux for 6 hours
3. 3
   その他After completion of the reaction

実験手順

To a mixture of 19 g (0.05 mol) of cholesta-1,4,6-trien-3-one (I), 4.8 g (0.05 mol) of methanesulfonic acid and 200 g (2 mol) of isopropenyl acetate were added 200 ml of toluene, and the resulting mixture was then heated under reflux for 6 hours. After completion of the reaction, the same treatment as in Example 1 was carried out to yield 11.7 g of cholesta-1,5,7-trien-3-ol (IV). The yield was 61%.

出典