反応 #40793

反応方程式

1-bromo-4-methylbenzene

lithium phenylacetylide

triisopropoxylborane

→

1-(2-p-Tolylethynyl)benzene

溶媒

DME THF

DME

反応条件

後処理

1. 1
   workup.ADDITIONwas added
2. 2
   その他the solution was degassed for another 5 min.

実験手順

General Procedure A. To a solution of lithium phenylacetylide (15.2 ml, 15.2 mmol) in DME (20 ml) under Argon at −78° C. was added triisopropoxylborane (3.5 ml, 15.2 mmol). The mixture was stirred at −78° C. for 1.5 hours. A solution of 1-bromo-4-methylbenzene (2 g, 11.7 mmol) in DME/THF (10 ml/10 ml) was degassed with dry argon, Pd(PPh3)4 (405 mg, 0.35 mmol) was added and the solution was degassed for another 5 min.

出典