反応 #40781

反応方程式

Bis-(2-chloro-ethyl)-amine hydrochloride

K2CO3

benzylbromide

→

colorless oil

Benzyl-bis-(2-chloro-ethyl)-amine

溶媒

acetonitrile

反応条件

後処理

1. 1
   workup.ADDITIONAdded
2. 2
   温度The mixture was refluxed overnight
3. 3
   濃縮Concentration
4. 4
   その他on silica and purification with flash column chromatography (eluents PA:ether=95:5)

実験手順

Bis-(2-chloro-ethyl)-amine hydrochloride was suspended in 150 mL acetonitrile. Added were 34.8 g K2CO3 (3 equiv.) and 10.0 mL benzylbromide (1 equiv.). The mixture was refluxed overnight, Concentration on silica and purification with flash column chromatography (eluents PA:ether=95:5) yielded 4.11 g of a colorless oil. 1H NMR (400 MHz, CDCl3) δ 2.93 (t, J=7 Hz, 4H), 3.50 (t, J=7 Hz, 4H), 3.74 (s, 2H), 7.22-7.37 (m, 5H).

出典