反応 #40751

反応方程式

acetic acid

NaBH(OAc)3

(1-ethyl-2-naphthalen-1-yl-1H-imidazol-4-yl)-piperidin-4-yl-methanol

cyclobutanone

→

title compound

(1-cyclobutyl-piperidin-4-yl)-(1-ethyl-2-naphthalen-1-yl-1H-imidazol-4-yl)-methanol

溶媒

CH2Cl2

—

CH2ClCH2Cl

反応条件

後処理

1. 1
   洗浄washed with Na2CO3 (1M), H2O and brine
2. 2
   その他dried
3. 3
   その他solvent removed
4. 4
   その他The crude is purified by column (2% Et3N, 3% MeOH in EtOAc)

実験手順

To a solution of (1-ethyl-2-naphthalen-1-yl-1H-imidazol-4-yl)-piperidin-4-yl-methanol (0.53 g) in CH2ClCH2Cl (12 ml) is added cyclobutanone (0.95 ml), followed by NaBH(OAc)3 and acetic acid (0.1 ml). The resulting mixture is stirred at rt overnight, diluted with CH2Cl2, washed with Na2CO3 (1M), H2O and brine, dried and solvent removed. The crude is purified by column (2% Et3N, 3% MeOH in EtOAc) to afford the title compound as a white solid, LCMS 390.1 (M+1).

出典