反応 #40737

反応方程式

4,5-dibromo-1-ethyl-2-naphthalen-1-yl-1H-imidazole

n-BuLi

hexane

n-BuLi

hexane

chlorotrimethylsilane

diethyl carbonate

tetrabutylammonium fluoride

→

1-ethyl-2-naphthalen-1-yl-1H-imidazole-4-carboxylic acid ethyl ester

溶媒

THF

THF

Water

THF

反応条件

後処理

1. 1
   workup.STIRRINGThe resulting solution is stirred at −78° C
2. 2
   workup.WAITAfter 1 hour
3. 3
   workup.STIRRINGThe resulting mixture is stirred at −78° C. for 1 hr
4. 4
   workup.STIRRINGThe resulting solution is stirred at −78° C. for 30 min
5. 5
   その他waned to rt
6. 6
   workup.STIRRINGstirred for an additional 30 min at rt
7. 7
   その他to quench
8. 8
   その他the reaction, and THF
9. 9
   その他is evaporated under reduced pressure
10. 10
    抽出The residue is extracted with EtOAc (30 ml×2)
11. 11
    洗浄The combined organic layers are washed with water and brine
12. 12
    乾燥dried over sodium sulfate
13. 13
    濃縮concentrated
14. 14
    その他to give the crude product, which
15. 15
    workup.STIRRINGthe resulting mixture is stirred at it for 2 hr
16. 16
    その他The solvent is evaporated under reduced pressure
17. 17
    workup.ADDITIONthe residue is diluted with water (30 ml)
18. 18
    抽出The mixture is extracted with EtOAc (30 ml×3)
19. 19
    洗浄washed with water and brine
20. 20
    乾燥dried over Na2SO4
21. 21
    濃縮concentrated
22. 22
    その他Purification through silica gel chromatography (hexanes/EtOAc, from 8:1 to 4:1)

実験手順

To a solution of 4,5-dibromo-1-ethyl-2-naphthalen-1-yl-1H-imidazole (3.80 g, 10 mmol) in anhydrous THF (60 ml) at −78° C. under nitrogen is added a solution of n-BuLi in hexane (1.6 M, 6.88 ml, 11 mmol, 1.1 eq.) dropwise. The resulting mixture is stirred at −78° C. for 1 hr, after which chlorotrimethylsilane (1.188 g, 11 mmol, 1.1 eq.) is added. The resulting solution is stirred at −78° C. After 1 hour, n-BuLi in hexane (1.6 M, 6.88 ml, 11 mmol, 1.1 eq.) is added dropwise. The resulting mixture is stirred at −78° C. for 1 hr, followed by the addition of diethyl carbonate (3.54 g, 30 mol, 3.0 eq.). The resulting solution is stirred at −78° C. for 30 min, waned to rt slowly, and stirred for an additional 30 min at rt. Water (30 ml) is added to quench the reaction, and THF is evaporated under reduced pressure. The residue is extracted with EtOAc (30 ml×2). The combined organic layers are washed with water and brine, dried over sodium sulfate, and concentrated to give the crude product, which is dissolved in THF (30 ml). To this THF solution is added tetrabutylammonium fluoride (1.1 eq.), and the resulting mixture is stirred at it for 2 hr. The solvent is evaporated under reduced pressure, and the residue is diluted with water (30 ml). The mixture is extracted with EtOAc (30 ml×3), washed with water and brine, dried over Na2SO4 and concentrated. Purification through silica gel chromatography (hexanes/EtOAc, from 8:1 to 4:1) affords 1-ethyl-2-naphthalen-1-yl-1H-imidazole-4-carboxylic acid ethyl ester. LCMS 295 (M+1).

出典