反応 #4072

反応方程式

(S)-2-(5-chloro-6-methoxy-2-naphthyl)-propionic acid

→

(S)-2-(6-methoxy-2-naphthyl)propionic acid

溶媒

sodium hydroxide

反応条件

後処理

1. 1
   ろ過it is filtered
2. 2
   workup.ADDITIONdiluted with excess dilute hydrochloric acid
3. 3
   抽出extracted with methylene chloride
4. 4
   その他The organic phase is evaporated to dryness
5. 5
   その他the residue recrystallized from methylene chloride/hexane

実験手順

A solution of 1 g of (S)-2-(5-chloro-6-methoxy-2-naphthyl)-propionic acid in 20 ml of 10% aqueous sodium hydroxide solution at 90° C. is treated with 3 g of a nickel-aluminum alloy in small portions. After stirring the mixture for two hours, it is filtered, diluted with excess dilute hydrochloric acid and extracted with methylene chloride. The organic phase is evaporated to dryness and the residue recrystallized from methylene chloride/hexane to yield (S)-2-(6-methoxy-2-naphthyl)propionic acid after recrystallization.

出典