反応 #40710

反応方程式

4-morpholinoacetophenone

N,N-dimethylformamide dimethyl acetal

hydrazine hydrate

→

title compound

4-[4-(1H-Pyrazol-3-yl)phenyl]morpholine

溶媒

methanol

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度under reflux for 7 hours
3. 3
   温度again heated
4. 4
   温度under reflux for about 6 hours
5. 5
   その他The solid formed
6. 6
   温度on cooling the mixture
7. 7
   ろ過was filtered off with suction
8. 8
   洗浄thoroughly washed with methanol

実験手順

A mixture of 2.05 g of 4-morpholinoacetophenone (10 mmol) and N,N-dimethylformamide dimethyl acetal was heated under reflux for 7 hours. The mixture was then mixed with 30 ml of methanol and, after addition of 0.57 ml of hydrazine hydrate, again heated under reflux for about 6 hours. The solid formed on cooling the mixture was filtered off with suction and thoroughly washed with methanol, resulting in 3.8 g of the title compound.

出典