反応 #40707

反応方程式

H2O

EDC

dichloroacetic acid

N-[1-(2-amino-1-hydroxy-2-oxoethyl)pentyl]-2-(4-phenyl-1H-pyrazol-1-yl)pyridine-3-carboxamide

→

title compound

収率 76.0%

N-{1-[Amino(oxo)acetyl]pentyl}-2-(4-phenyl-1H-pyrazol-1-yl)nicotinamide

収率 76.0%

溶媒

dimethyl sulfoxide

反応条件

後処理

1. 1
   ろ過the resulting precipitate was filtered off with suction
2. 2
   その他dried in a vacuum
3. 3
   その他drying oven at 40° C

実験手順

0.47 g of EDC and 0.08 ml of dichloroacetic acid were added to 100 mg of N-[1-(2-amino-1-hydroxy-2-oxoethyl)pentyl]-2-(4-phenyl-1H-pyrazol-1-yl)pyridine-3-carboxamide (0.25 mmol) in 4 ml of dimethyl sulfoxide, and the mixture was stirred at room temperature overnight. For workup, the reaction mixture was poured into H2O, and the resulting precipitate was filtered off with suction and dried in a vacuum drying oven at 40° C. 77 mg of the title compound were obtained as an amorphous white solid.

出典