反応 #40677

反応方程式

20f

2-(1′-neopentylspiro[indoline-3,4′-piperidine]-1-yl)aniline

benzoylisothiocyanate

→

N-(2-(1′-neopentylspiro[indoline-3,4′-piperidine]-1-yl)phenylcarbamothioyl)benzamide

溶媒

DCM

反応条件

後処理

1. 1
   濃縮The reaction was concentrated
2. 2
   その他the residue was purified by flash chromatography (silica gel, 0-10% MeOH/DCM)
3. 3
   その他to give 20 g

実験手順

A mixture of 20f (118 mg, 0.33 mmol) and benzoylisothiocyanate (63 μL, 0.47 mmol) in DCM (3 mL) was stirred at rt for 3 h. The reaction was concentrated and the residue was purified by flash chromatography (silica gel, 0-10% MeOH/DCM) to give 20 g, as yellow solid (156 mg). LC-MS m/z 513.06 [M+H]+.

出典