反応 #40660

反応方程式

1b

4,4-dimethyl-1,2,3,4-tetrahydroquinoline

ortho-fluoronitrobenzene

2,4,6-collidine

→

1c

4,4-dimethyl-1-(2-nitro-phenyl)-1,2,3,4-tetrahydro-quinoline

溶媒

CHCl3

反応条件

後処理

1. 1
   温度It was then heated
2. 2
   その他was purified by flash chromatography (hexanes/EtOAc)

実験手順

1b (0.762 g, 4.73 mmol), ortho-fluoronitrobenzene (0.88 g, 5.67 mmol, 1.19 eq), and 2,4,6-collidine (0.66 mL, 1.05 eq) were pre-stirred 40s in a conical microwave container. It was then heated with stirring at a Personal Chemistry Microwave reactor with normal absorption at 250° C. for 1 h. The crude mixture was dissolved in CHCl3, and was purified by flash chromatography (hexanes/EtOAc) to give 0.66 g of crude 1c. LC-MS ESI 283 (M+H).

出典