反応 #40629

反応方程式

m-CPBA

8-cyclohexyl-2-methylsulfanyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

Na2SO3

→

title compound

8-Cyclohexyl-2-methanesulfonyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

溶媒

dichloromethane

反応条件

後処理

1. 1
   その他the mixture was partitioned between sat. NaHCO3 and dichloromethane
2. 2
   乾燥The organic layer was dried (MgSO4)
3. 3
   濃縮concentrated

実験手順

m-CPBA (0.33 g, 1.5 mmol of a 70% w/w mixture) was added to a solution of 8-cyclohexyl-2-methylsulfanyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (0.206 g, 0.59 mmol) in dichloromethane (15 mL). After 2 hours, a 10% solution of Na2SO3 (1 mL) was added and the mixture was partitioned between sat. NaHCO3 and dichloromethane. The organic layer was dried (MgSO4) and concentrated to provide 0.22 g of the title compound. Mass Spectrum (LCMS, ESI pos.) Calcd. For C17H21N3O5S: 379.12. found: (M+H) 380.1.

出典