反応 #40626

反応方程式

Cyclohexylamine

3-chloro-propionic acid ethyl ester

K2CO3

→

title compound

収率 72.3%

3-Cyclohexylamino-propionic acid ethyl ester

収率 72.3%

反応条件

後処理

1. 1
   その他The resulting mixture was then partitioned between water and dichloromethane
2. 2
   乾燥The organic layer was dried (MgSO4)
3. 3
   濃縮concentrated

実験手順

Cyclohexylamine (0.86 g, 8.7 mmol) and 3-chloro-propionic acid ethyl ester (1.18 g, 8.67 mmol) were combined neat and K2CO3 (1.2 g, 8.7 mmol) and a catalytic amount of tetrabutylammonium iodide (ca. 5 mg) was added. The mixture was heated at 80° C. overnight. The resulting mixture was then partitioned between water and dichloromethane. The organic layer was dried (MgSO4) and concentrated to afford 1.25 g (72%) of the title compound.

出典