反応 #40458

反応方程式

6-chloro-7-methoxy-9H-β-carbolin-8-ylamine

EDCI

2-methyl nicotinic acid

→

desired product

収率 50.0%

N-(6-chloro-7-methoxy-9H-β-carbolin-8-yl)-2-methyl-nicotinamide

収率 50.0%

溶媒

pyridine

反応条件

後処理

1. 1
   その他The pyridine was then removed by rotary evaporation and 5% Na2CO3 solution
2. 2
   workup.ADDITIONwas added
3. 3
   その他The resulting solid that precipitated out
4. 4
   ろ過was collected by filtration
5. 5
   その他Chromatographic purification

実験手順

6-chloro-7-methoxy-9H-β-carbolin-8-ylamine (100 mg, 0.4 mmol), EDCI (125 mg, 0.64 mmol) and 2-methyl nicotinic acid (66 mg, 0.48 mmol) were taken in a round-bottom flask and suspended in pyridine (2 ml). The resulting mixture was heated at 80° C. overnight. The pyridine was then removed by rotary evaporation and 5% Na2CO3 solution was added. The resulting solid that precipitated out was collected by filtration. Chromatographic purification gave the desired product in 50-70% yield.

出典