反応 #40424

反応方程式

citraconic anhydride

2-amino-5-bromopyridine

→

solid

収率 71.0%

N-(5-bromopyridin-2-yl)-methylmaleimide

収率 71.0%

溶媒

toluene

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度to reflux overnight
3. 3
   温度The solution was cooled down
4. 4
   ろ過filtered
5. 5
   濃縮The filtrate was concentrated in vacuo

実験手順

A mixture of citraconic anhydride (1.00 mL, 11.1 mmol) and 2-amino-5-bromopyridine (1.93 g, 11.2 mmol) in toluene (60 mL) was heated to reflux overnight. The solution was cooled down, filtered. The filtrate was concentrated in vacuo to give a solid (2.10 g, yield: 71%). MS 267 and 269 (M+H).

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