反応 #40419

反応方程式

N-(5-chloro(2-pyridyl)){6-[(4-cyanophenyl)-carbonylamino]-3-hydroxyphenyl}carboxamide

Cs2CO3

ethyl bromoacetate

→

crude compound

収率 112.4%

ethyl 2-{3-[N-(5-chloro(2-pyridyl))carbamoyl]-4-[(4-cyanophenyl)carbonylamino]-phenoxy}acetate

収率 112.4%

溶媒

DMF

EtOAc

water

反応条件

後処理

1. 1
   洗浄The organic layer was washed with brine
2. 2
   その他dried
3. 3
   その他evaporated

実験手順

To a mixture of compound N-(5-chloro(2-pyridyl)){6-[(4-cyanophenyl)-carbonylamino]-3-hydroxyphenyl}carboxamide (50 mg, 0.13 mmol) and Cs2CO3 (83 mg, 0.25 mmol) in DMF (1 mL) at room temperature was added ethyl bromoacetate (15 μL, 0.13 mmol). The mixture was stirred for 1 hour before diluted with EtOAc (20 mL) and water (10 mL). The organic layer was washed with brine dried and evaporated to give 70 mg of the crude compound, which was used without further purification. MS found for C24H19ClN4O3 (M+H)+: 479.0.

出典