反応 #40405

反応方程式

N-(5-chloro(2-pyridyl))(5-methyl-2-nitrophenyl)carboxamide

hydrogen

→

(2-aminophenyl)-N-(2-pyridyl)carboxamide

chloride

溶媒

methanol

反応条件

後処理

1. 1
   その他at r.t.
2. 2
   その他for 2 hrs
3. 3
   ろ過After the filtration by Celite
4. 4
   濃縮the filtrate was concentrated

実験手順

To a solution of the compound of N-(5-chloro(2-pyridyl))(5-methyl-2-nitrophenyl)carboxamide (1.48 g, 5.1 mmol) in methanol (10 ml) was added 5% Pt/C (1.48 g, 0.19 mmol). The mixture was applied hydrogen balloon at r.t. for 2 hrs. After the filtration by Celite, the filtrate was concentrated to give (2-aminophenyl)-N-(2-pyridyl)carboxamide, C, chloride, N (1.36 g, 100%). MS found for C13H12ClN3O M+=262, (M+2)+=264.

出典