反応 #40391

反応方程式

water

benzyloxy-8-(2-ethoxy-2-hydroxyacetyl)-4H-benzo[1,4]oxazin-3-one

ethyl 4-[4-(2-amino-2-methylpropyl)phenoxy]butyrate

oxalic acid

→

ethyl 4-(4-{2-[2-(6-benzyloxy-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-8-yl)2-hydroxyethylamino]-2-methylpropyl}phenoxy)butyrate

溶媒

diethyl ether

ethyl acetate

反応条件

後処理

1. 1
   その他the solid precipitated
2. 2
   ろ過filtered
3. 3
   洗浄washed with diethyl ether

実験手順

1.20 g (3.36 mmol) of benzyloxy-8-(2-ethoxy-2-hydroxyacetyl)-4H-benzo[1,4]oxazin-3-one and 0.90 g (3.22 mmol) of ethyl 4-[4-(2-amino-2-methylpropyl)phenoxy]butyrate are reacted in the manner described for Example 8(d). The crude product is dissolved in 10 mL ethyl acetate and 10 mL water and combined with oxalic acid with stirring. The solution is diluted with diethyl ether and the solid precipitated is suction filtered and washed with diethyl ether. Yield: 1.20 g (54%, oxalate); melting point 223° C.-227° C.

出典