反応 #40333

反応方程式

water

N-bromosuccinimide

sodium acetate

trimethyl-(3-methyl-cyclohex-1-enyloxy)-silane

→

title compound

2-bromo-3-methyl-cyclohexanone

溶媒

THF water

ethyl acetate

反応条件

実験手順

A solution of N-bromosuccinimide (0.48 mmol) and sodium acetate (0.04 mmol) in THF/water (1:1, 5.2 ml) is cooled to 0° C. and trimethyl-(3-methyl-cyclohex-1-enyloxy)-silane (0.4 mmol, 80% pure) is added dropwise. The reaction mixture is heated to room temperature and stirring is continued overnight. After addition of water extraction is carried out with ethyl acetate. The title compound is obtained from the combined organic phases after drying over sodium sulphate and evaporating-off of the solvent in a vacuum (JOC 1997, 62, 19, 6692-6696).

出典