反応 #40320

反応方程式

2-guanidino-4,5,6,7-tetrahydro-benzothiazole-4-carboxylic acid ethyl ester

sodium hydroxide

hydrochloric acid

→

title compound

収率 56.0%

Guanidino-4,5,6,7-tetrahydro-benzothiazole-4-carboxylic acid

収率 56.0%

溶媒

methanol water

反応条件

後処理

1. 1
   ろ過the precipitated product is filtered off

実験手順

A suspension of 2-guanidino-4,5,6,7-tetrahydro-benzothiazole-4-carboxylic acid ethyl ester (5 mmol) and sodium hydroxide (20 mmol) in methanol/water (4:1, 10 ml) is stirred overnight at room temperature. The pH is set at 5 by adding 25% hydrochloric acid and the precipitated product is filtered off. In this way the title compound is obtained (671 mg) in a yield of 56%: tR 0.64 min (LC-1); ESI-MS (+/−): m/z 241.49 [M+H]+/239.37 [M−H]−.

出典