反応 #40297

反応方程式

2-imino-4-thiobiuret

2-bromo-4-isopropyl-cyclohexanone

ethyl acetate

→

rac. N-(6-isopropyl-4,5,6,7-tetrahydro-benzothiazole-2-yl)-guanidine

溶媒

ethanol

反応条件

後処理

1. 1
   温度the reaction mixture is then refluxed for 16 hours
2. 2
   その他the precipitated-out product is isolated
3. 3
   ろ過by filtering off

実験手順

2-imino-4-thiobiuret (5 mmol) is added accompanied by stirring to a solution of 2-bromo-4-isopropyl-cyclohexanone (5 mmol) in ethanol (10 ml) and the reaction mixture is then refluxed for 16 hours. After evaporating-off of the solvent ethyl acetate is added to the residue and the precipitated-out product is isolated by filtering off: tR 2.75 min (LC-1, one peak); ESI-MS (+/−): m/z 239.25 [M+H]+/237.24 [M−H]−.

出典