反応 #40295

反応方程式

compound

(2R)—N-tert-Butoxycarbonyl-3-trimethylsilylalanine

Trimethylsilyl chloride

→

(2R)-3-Trimethylsilylalanine methyl ester hydrochloride

溶媒

methanol

反応条件

後処理

1. 1
   温度the mixture is warmed to RT overnight
2. 2
   その他The volatile components are removed on a Rotavapor and subsequently under high vacuum
3. 3
   その他The target compound (224 mg, 92% of th.) is obtained

実験手順

The compound of Example 6A (300 mg) is dissolved in methanol (3 ml) and cooled to 0° C. Trimethylsilyl chloride (590 mg, 4.7 eq.) is added dropwise in the course of 30 min. and the mixture is warmed to RT overnight. The volatile components are removed on a Rotavapor and subsequently under high vacuum. The target compound (224 mg, 92% of th.) is obtained.

出典