反応 #4027

反応方程式

2-(p-methoxyphenyl)-5-octylpyridine

hydrobromic acid

water

→

2-(p-hydroxyphenyl)-5-octylpyridine

溶媒

acetic acid

反応条件

後処理

1. 1
   温度the solution was heated for 15 hours
2. 2
   温度under reflux
3. 3
   抽出the organic layer was extracted with chloroform
4. 4
   洗浄After washing the
5. 5
   抽出extract three times with water
6. 6
   その他the chloroform was removed by distillation
7. 7
   その他The residue was recrystallized from a mixture of acetone and hexane

実験手順

The 2-(p-methoxyphenyl)-5-octylpyridine was dissolved in 100 ml of acetic acid. 8 ml of 48% hydrobromic acid was added to the reaction solution and the solution was heated for 15 hours under reflux. 100 ml of water was added to the reaction solution and the organic layer was extracted with chloroform. After washing the extract three times with water, the chloroform was removed by distillation. The residue was recrystallized from a mixture of acetone and hexane to yield 8.3 g (0.029 mol) of 2-(p-hydroxyphenyl)-5-octylpyridine.

出典