反応 #4020

反応方程式

3-amino-2-mercaptopyridine

2-chloro-1,1,1-triethoxyethane

→

2-Chloromethylthiazolo[5,4-b]pyridine

溶媒

ethanol

ethanol

反応条件

後処理

1. 1
   その他prepared by the method of J
2. 2
   その他was chromatographed over silica gel
3. 3
   その他to obtain the product (2.94 g; m.p. 71°-73° C.)

実験手順

A mixture of 3-amino-2-mercaptopyridine (3.6 g) prepared by the method of J. Org. Chem., 29, 2652 (1963), 2-chloro-1,1,1-triethoxyethane (6.5 g) and ethanol (60 ml) was heated at 60° C. for 4 hours. The crude solid resulting from evaporation of ethanol was chromatographed over silica gel to obtain the product (2.94 g; m.p. 71°-73° C.).

出典