反応 #4017

反応方程式

2-chloro-1,1,1-triethoxyethane

2-aminothiophenol

→

2-chloromethylbenzothiazole

収率 91.3%

溶媒

methylene chloride

反応条件

後処理

1. 1
   洗浄the resulting solution was washed with 3N HCl (10 ml)
2. 2
   その他The organic portion was evaporated
3. 3
   その他the residue chromatographed over silica gel

実験手順

A solution of 2-chloro-1,1,1-triethoxyethane (5.9 g) and 2-aminothiophenol (2.5 g) was heated at 80° C. for 15 minutes. After cooling to room temperature, it was dissovled in methylene chloride (30 ml) and the resulting solution was washed with 3N HCl (10 ml) and then with water (20 ml). The organic portion was evaporated and the residue chromatographed over silica gel to obtain 2-chloromethylbenzothiazole (3.35 g; 90% yield), m.p. 34° C.

出典