反応 #3985

反応方程式

4-Amino-1-(naphth-2-ylmethyl)piperidine

benzoylisothiocyanate

→

1-Benzoyl-3-[1-(naphth-2-ylmethyl)piperid-4-yl]thiourea

溶媒

toluene

反応条件

後処理

1. 1
   その他The solvent was evaporated
2. 2
   workup.DISSOLUTIONthe gum dissolved in isopropyl alcohol
3. 3
   その他The solvent was evaporated
4. 4
   workup.DISSOLUTIONthe residue dissolved in ethyl acetate
5. 5
   その他The title compound crystallised
6. 6
   ろ過was filtered
7. 7
   乾燥dried as the monohydrochloride quarterhydrate salt, m.p. 212°-214° C.

実験手順

4-Amino-1-(naphth-2-ylmethyl)piperidine (1.0 g, 0.0042 m) and benzoylisothiocyanate (0.69 g, 0.0042 m) in toluene (120 cm3) was stirred at room temperature for 6 hours. The solvent was evaporated and the gum dissolved in isopropyl alcohol and acidified with ethanolic HCl. The solvent was evaporated and the residue dissolved in ethyl acetate. The title compound crystallised and was filtered and dried as the monohydrochloride quarterhydrate salt, m.p. 212°-214° C.

出典