反応 #3973
ord-6a823073ab7c4f51901f88aec89eb947
反応方程式
acetic acid
8-(2-methoxy-4-carboxy-phenyl)-1H,-3H-purin-2,6-dione
ammonia
water
→
8-(2-Methoxy-4-aminocarbonyl-phenyl)-1H,3H-purin-2,6-dione
反応条件
詳細条件
See reaction.notes.procedure_details.
後処理
- 1その他the product precipitated
- 2ろ過is filtered off
実験手順
A quantity of 2.3 gm of 8-(2-methoxy-4-carboxy-phenyl)-1H,-3H-purin-2,6-dione are refluxed for one hour in 50 ml of thionyl chloride with the addition of 1 drop of dimethylformamide. The excess thionyl chloride is drawn off, and the residue is stirred for 16 hours at ambient temperature with a solution of ammonia in dimethylformamide. The dimethylformamide is drawn off, the remainder is mixed with water and acidified with glacial acetic acid, and the product precipitated is filtered off.