反応 #3968

反応方程式

2-[2-methoxy-5-nitro-4-(4,4-dimethyl-7-nitro-2H,4H-isoquinolin-1,3-dione-2-yl)-phenyl]-5-methoxy-imidazo[4,5-b]pyridine

hydrazine hydrate

→

2-(2-Methoxy-4-amino-5-nitro-phenyl)-5-methoxy-imidazo[4,5-b]pyridine

溶媒

isopropanol

反応条件

後処理

1. 1
   温度refluxed for 1.75 hours
2. 2
   濃縮The reaction mixture is concentrated by evaporation
3. 3
   その他the residue is triturated with 50 ml of ice water
4. 4
   その他the product precipitated
5. 5
   その他is purified by chromatography on silica gel [eluant: methylene chloride/ethanol (100:0 to 100:2)]

実験手順

One half gram of 2-[2-methoxy-5-nitro-4-(4,4-dimethyl-7-nitro-2H,4H-isoquinolin-1,3-dione-2-yl)-phenyl]-5-methoxy-imidazo[4,5-b]pyridine is suspended in 10 ml of isopropanol, mixed with 0.5 ml of 80% hydrazine hydrate, and refluxed for 1.75 hours with stirring. The reaction mixture is concentrated by evaporation, the residue is triturated with 50 ml of ice water, and the product precipitated is purified by chromatography on silica gel [eluant: methylene chloride/ethanol (100:0 to 100:2)].

出典