反応 #3950

反応方程式

2-(2-dimethylamino-4-nitro-phenyl)-5-methoxy-imidazo[4,5-b]pyridine

hydrochloric acid

→

2-(2-Dimethylamino-4-nitro-phenyl)-4H-imidazo[4,5-b]pyridin-5-one

溶媒

反応条件

後処理

1. 1
   抽出neutralized, and extracted with ethyl acetate
2. 2
   洗浄After washing with water
3. 3
   乾燥drying with magnesium sulfate
4. 4
   その他the ethyl acetate phase is evaporated
5. 5
   その他The residue is crystallized by trituration in ether/petroleum ether

実験手順

A quantity of 0.2 gm of 2-(2-dimethylamino-4-nitro-phenyl)-5-methoxy-imidazo[4,5-b]pyridine is heated in a bomb tube to 100° C. for three hours with 5 ml of concentrated hydrochloric acid. The reaction mixture is poured onto about 20 ml of ice, neutralized, and extracted with ethyl acetate. After washing with water and drying with magnesium sulfate, the ethyl acetate phase is evaporated. The residue is crystallized by trituration in ether/petroleum ether.

出典