反応 #3946

反応方程式

2-(2-methoxy-4-methylsulfinyl-phenyl)-5H-imidazo[4,5-d]pyridazin-4-one

hydrogen peroxide

hydrogen peroxide

→

2-(2-Methoxy-4-methylsulfonyl-phenyl)-5H-imidazo[4,5-d]pyridazin-4-one

溶媒

acetic acid

反応条件

後処理

1. 1
   workup.WAITfor two hours at 40°-50° C.
2. 2
   温度the mixture is heated for another hour
3. 3
   その他The product precipitated
4. 4
   ろ過is subjected to suction filtration
5. 5
   洗浄washed with ether

実験手順

A quantity of 0.07 gm of 2-(2-methoxy-4-methylsulfinyl-phenyl)-5H-imidazo[4,5-d]pyridazin-4-one is dissolved in 5 ml of glacial acetic acid, mixed with 0.05 ml of 30% hydrogen peroxide, and stirred first for 55 minutes at ambient temperature then for two hours at 40°-50° C., Then, a further 0.05 ml of hydrogen peroxide are added, and the mixture is heated for another hour. The product precipitated is subjected to suction filtration and washed with ether.

出典